Mass Immunization Against Diphtheria with Sordelli's Toxoid and Contact Immunization

Immunization with Tetanus Toxoid

Although immunization with tetanus toxoid cannot be expected to produce an adequate permanent immunity, a number of investigators have confirmed and extended the observation of Ramon3 to the effect that an organism, once immunized, will respond to further injections of toxoid with an accelerated and increased antitoxin production. That this response to the "injection de rappel" does occur has b...

Diphtheria Immunization *

AT the beginning of the twentieth century diphtheria occupied a unique position in contrast to other infectious diseases. Its symptoms and course were well known and accurately described, the causal organism definitely recognized, and a specific remedy was available for its treatment, yet in spite of this wealth of scientific knowledge the control and prevention of the disease had proved a comp...

Protection against group A streptococcus by immunization with J8-diphtheria toxoid: contribution of J8- and diphtheria toxoid-specific antibodies to protection.

A conformationally constrained, minimally conserved peptide from the M protein of group A streptococcus (GAS) has been defined. It consists of 12 amino acids from the C-repeat region within a non-M protein helix-forming sequence and is referred to as "J8." Here, we investigate the immunogenicity of a J8-diphtheria toxoid (DT) conjugate adjuvanted with the human-compatible adjuvants, SBAS2 and a...

Oral Immunization against Diphtheria and Tetanus Infections by Fluid Dphtheria and Tetanus Toxoids

Cellobiose-coated poly (lactide-co-glycolide) particles loaded with diphtheria toxoid for per os immunization

AIM To evaluate the dose-dependent immunogenic properties of poly(lactide-co-glycolide) (PLGA) particles coated with cellobiose as antigen carriers for oral immunization. METHODS Two types of PLGA-cellobiose particles (PLGA-cellobiose-1, ~ 0.8 μm and PLGA-cellobiose-2, ~ 1.2 μm) containing non-toxic recombinant subunit B (SbB) of diphtheria toxin fused with enhanced green fluorescent protein ...